Irf2bp2 Gene Summary [Mouse]
Predicted to enable transcription corepressor activity. Predicted to be involved in immature B cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; diaphragm; liver; lung; and musculature. Human ortholog(s) of this gene implicated in common variable immunodeficiency 14. Orthologous to human IRF2BP2 (interferon regulatory factor 2 binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irf2bp2 |
| Official Name | interferon regulatory factor 2 binding protein 2 [Source:MGI Symbol;Acc:MGI:2443921] |
| Ensembl ID | ENSMUSG00000051495 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 2 binding protein 2 |
| Synonyms | CVID14, E130305N23RIK, interferon regulatory factor 2 binding protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Irf2bp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ring like zinc finger domain
- transcription regulator
- transcription co-repressor
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Interferon regulatory factor 2-binding protein zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lymphatic neoplasia
- T-cell non-Hodgkin disease
- hematologic cancer
- common variable immunodeficiency type 14
- mature T-cell neoplasia
- adult T-cell leukemia/lymphoma
- lymphomagenesis
- lymphoid cancer
- hematological neoplasia
role in cell
- expression in
- production in
- apoptosis
- differentiation
- transcription in
- transactivation in
- JQ1 resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Irf2bp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- immature B cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor activity
- metal ion binding