Elmo2 Gene Summary [Mouse]
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in actin filament organization and cell chemotaxis. Predicted to be located in cytosol and membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; nervous system; and retina. Orthologous to human ELMO2 (engulfment and cell motility 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elmo2 |
| Official Name | engulfment and cell motility 2 [Source:MGI Symbol;Acc:MGI:2153045] |
| Ensembl ID | ENSMUSG00000017670 |
| Bio databases IDs | |
| Aliases | engulfment and cell motility 2 |
| Synonyms | 1190002F24Rik, CED-12, Ced-12A, engulfment and cell motility 2, LOC102555457, VMPI |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elmo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELMO, armadillo-like helical domain
- receptor tyrosine kinase binding
- ELMO/CED-12 family
- protein binding
- Pleckstrin homology-like domain
- Pleckstrin homology domain
Pathways
Biological processes and signaling networks where the Elmo2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary intraosseous vascular malformation
- dystrophy
role in cell
- activation in
- outgrowth
- migration
- polarization
- fusion
- binding in
- chemotaxis
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elmo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell motility
- apoptotic process
- phagocytosis
- actin filament organization
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding
- receptor tyrosine kinase binding