Sh2b2 Gene Summary [Mouse]
Enables transmembrane receptor protein tyrosine kinase adaptor activity. Involved in intracellular signal transduction. Acts upstream of or within several processes, including B-1 B cell homeostasis; brown fat cell differentiation; and cell surface receptor signaling pathway. Located in actin filament; ruffle; and stress fiber. Is expressed in dorsal aorta. Orthologous to human SH2B2 (SH2B adaptor protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sh2b2 |
| Official Name | SH2B adaptor protein 2 [Source:MGI Symbol;Acc:MGI:1345171] |
| Ensembl ID | ENSMUSG00000005057 |
| Bio databases IDs | |
| Aliases | SH2B adaptor protein 2 |
| Synonyms | APS, SH2B2alpha, SH2B adaptor protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sh2b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- SH2-domain binding
- protein binding activity, bridging
- PH domain
- Phenylalanine zipper
- Src homology 2 (SH2) domain
- protein binding
- Pleckstrin homology-like domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- identical protein binding
Pathways
Biological processes and signaling networks where the Sh2b2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- post-myeloproliferative neoplasm-acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
role in cell
- proliferation
- differentiation
- activation in
- quantity
- organization
- number
- homeostasis
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cellular membrane
- Plasma Membrane
- actin filaments
- cytosol
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sh2b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antigen receptor-mediated signaling pathway
- brown fat cell differentiation
- insulin receptor signaling pathway
- B-1 B cell homeostasis
- cytokine-mediated signaling pathway
- nervous system development
- regulation of Ras protein signal transduction
- regulation of metabolic process
- actin cytoskeleton organization
- intracellular signal transduction
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- stress fiber
- ruffle
- cytosol
- actin filament
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- signaling adaptor activity
- transmembrane receptor protein tyrosine kinase adaptor activity
- SH2 domain binding