SH2B2
SH2B2 Gene Summary
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | SH2B2 |
| Official Name | SH2B adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:17381] |
| Ensembl ID | ENSG00000160999 |
| Bio databases IDs | |
| Aliases | SH2B adaptor protein 2, adaptor protein with pleckstrin homology and src |
| Synonyms | APS,SH2B2alpha,SH2B adaptor protein 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- SH2-domain binding
- protein binding activity, bridging
- PH domain
- Phenylalanine zipper
- Src homology 2 (SH2) domain
- protein binding
- Pleckstrin homology-like domain
- transmembrane receptor protein tyrosine kinase adaptor protein
- identical protein binding
Pathways
Biological processes and signaling networks where the SH2B2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SH2B2
- ZNF414
- CBL
- KIT
- JAK2
- JAK1
- FGFR3
- NTRK1
- VAV3
- ASB6
disease
- post-myeloproliferative neoplasm-acute myeloid leukemia
- non-insulin-dependent diabetes mellitus
regulated by
- LY294002
- EGLN
- IFNG
- lipopolysaccharide
- dimethyl n-oxalyl-glycine
- PDGF-BB
- insulin
- AKT
- INSR
- L-triiodothyronine
regulates
- F Actin
- FOS
- JAK1
- JAK2
- MAPK
- IgG3
- STAT5A/B
- MAPK1
- c-Cbl
- SORBS1
role in cell
- proliferation
- differentiation
- activation in
- quantity
- organization
- number
- homeostasis
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- cellular membrane
- Plasma Membrane
- actin filaments
- cytosol
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SH2B2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- antigen receptor-mediated signaling pathway
- brown fat cell differentiation
- insulin receptor signaling pathway
- B-1 B cell homeostasis
- cytokine-mediated signaling pathway
- nervous system development
- regulation of Ras protein signal transduction
- regulation of metabolic process
- actin cytoskeleton organization
- intracellular signal transduction
- B cell receptor signaling pathway
CELLULAR COMPONENT
Where in the cell the gene product is active
- cytoplasm
- stress fiber
- ruffle
- cytosol
- actin filament
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- identical protein binding
- protein binding
- signaling adaptor activity
- transmembrane receptor protein tyrosine kinase adaptor activity
- SH2 domain binding