Vav3

Enables epidermal growth factor receptor binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb segment; metanephros; and sensory organ. Orthologous to human VAV3 (vav guanine nucleotide exchange factor 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vav3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Vav3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Vav3 gene, providing context for its role in the cell.