Dnah2 Gene Summary [Mouse]
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Involved in cilium movement. Located in motile cilium. Part of axonemal dynein complex. Is expressed in central nervous system. Human ortholog(s) of this gene implicated in spermatogenic failure 45. Orthologous to human DNAH2 (dynein axonemal heavy chain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnah2 |
| Official Name | dynein, axonemal, heavy chain 2 [Source:MGI Symbol;Acc:MGI:107731] |
| Ensembl ID | ENSMUSG00000005237 |
| Bio databases IDs | |
| Aliases | dynein, axonemal, heavy chain 2 |
| Synonyms | 2900022L05RIK, 4930564A01, axo f, D130094J20, D330014H01Rik, DLP2, DNAHC2, DNHD3, dynein axonemal heavy chain 2, dynein, axonemal, heavy chain 2, FLJ46675, LOC102556033, SPGF45 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnah2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR/MLP1/MLP2-like protein
- Dynein heavy chain C-terminal domain
- Ezrin/radixin/moesin, alpha-helical domain
- ATP-binding dynein motor region
- Microtubule-binding stalk of dynein motor
- AAA+ lid domain
- Dynein heavy chain, N-terminal region 1
- P-loop containing dynein motor region
- Dynein heavy chain, N-terminal region 2
- P-loop containing dynein motor region D4
- Dynein heavy chain AAA lid domain
- AAA domain (dynein-related subfamily)
- Dynein heavy chain region D6 P-loop domain
- Hydrolytic ATP binding site of dynein motor region
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- insulin-dependent diabetes mellitus
- spermatogenic failure 45
- uterine leiomyoma
- leiomyomatosis
- infectious mononucleosis
- non-melanoma skin cancer
regulates
- Axonemal Dynein Inner Arm
role in cell
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- cilia
- axonemes
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnah2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium movement involved in cell motility
- ciliary cell motility
- inner dynein arm assembly
Cellular Component
Where in the cell the gene product is active
- inner dynein arm
- motile cilium
- axonemal dynein complex
- dynein complex
- sperm flagellum
- axoneme
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- microtubule motor activity
- dynein light intermediate chain binding
- dynein intermediate chain binding
- minus-end-directed microtubule motor activity