Top2b Gene Summary [Mouse]
Enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in B cell differentiation. Acts upstream of or within axonogenesis; forebrain development; and neuron migration. Located in nucleus. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human TOP2B (DNA topoisomerase II beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Top2b |
| Official Name | topoisomerase (DNA) II beta [Source:MGI Symbol;Acc:MGI:98791] |
| Ensembl ID | ENSMUSG00000017485 |
| Bio databases IDs | |
| Aliases | topoisomerase (DNA) II beta |
| Synonyms | BILU, D230016L12RIK, DNA topoisomerase II beta, DNA topoisomerase II β, Top-2, top2beta, TOPIIB, Topo2 β, topoisomerase (DNA) II beta, topoisomerase (DNA) II β, Topoisomerase ii β |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Top2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal associated domain of TOPRIM
- TopoisomeraseII
- DNA topoisomerase (ATP-hydrolysing)
- Histidine kinase-like ATPase domain
- DNA gyrase B
- TOPRIM
- TopoII_MutL_Trans
- Toprim domain
- chromatin binding
- enzyme
- protein binding
- DNA topoisomerase
- ribonucleoprotein binding
- TOP4c
- DNA Topoisomerase IV
- DNA gyrase/topoisomerase IV, subunit A
- Histidine kinase-like ATPases
- DTHCT (NUC029) region
Pathways
Biological processes and signaling networks where the Top2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- locally advanced non-small cell lung cancer
- non-small cell lung cancer
- recurrent non-small cell lung cancer
- metastatic non-small cell lung cancer
- cancer
- leukemia
- prostatic adenocarcinoma
- prostate cancer
- precursor B-cell acute lymphoblastic leukemia
- T acute lymphoblastic leukemia
role in cell
- migration
- phosphorylation in
- expression in
- growth
- cell death
- cell viability
- apoptosis
- differentiation
- development
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- nuclear scaffolds
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Top2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sister chromatid segregation
- B cell differentiation
- cellular senescence
- resolution of meiotic recombination intermediates
- DNA topological change
- neuron migration
- forebrain development
- positive regulation of retroviral genome replication
- axonogenesis
- cellular response to hydrogen peroxide
- cellular response to ATP
- positive regulation of double-strand break repair via nonhomologous end joining
Cellular Component
Where in the cell the gene product is active
- heterochromatin
- nucleus
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ATP binding
- protein binding
- metal ion binding
- ribonucleoprotein complex binding
- chromatin binding
- DNA topoisomerase (ATP-hydrolyzing) activity