Uso1 Gene Summary [Mouse]
Acts upstream of or within several processes, including Golgi organization; regulation of cellular response to insulin stimulus; and small GTPase-mediated signal transduction. Located in cytosol and perinuclear region of cytoplasm. Is expressed in central nervous system and retina. Orthologous to human USO1 (USO1 vesicle transport factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Uso1 |
| Official Name | USO1 vesicle docking factor [Source:MGI Symbol;Acc:MGI:1929095] |
| Ensembl ID | ENSMUSG00000029407 |
| Bio databases IDs | |
| Aliases | USO1 vesicle docking factor |
| Synonyms | MGI:1929095, P115, TAP, Transcytosis associated protein p115, USO1 vesicle docking factor, USO1 vesicle transport factor, VDP, VESICLE DOCKING protein p115 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Uso1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein 16 (ATG16)
- Ciliary protein causing Leber congenital amaurosis disease
- Uso1 / p115 like vesicle tethering protein, C terminal region
- coiled-coil domain
- protein binding
- globular head domain
- Uso1p homology domain
- acidic domain
- Fez1
- Uso1 / p115 like vesicle tethering protein, head region
- Growth-arrest specific micro-tubule binding
- Armadillo tether-repeat of vescicular transport factor
- tail domain
Pathways
Biological processes and signaling networks where the Uso1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- obesity
- organismal death
role in cell
- growth
- activation in
- proliferation
- assembly
- invasion by
- fusion
- disruption
- fragmentation
- morphology
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- membrane fraction
- fibrillar center
- endoplasmic reticulum mitochondria contact site
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- microtubule organizing centers
- cytosol
- cisternae
- cis face of the Golgi apparatus
- Golgi membrane
- perinuclear space
- transport vesicles
- GLUT4 vesicles
- cis Golgi cisternae
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Uso1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- membrane fusion
- regulation of cellular response to insulin stimulus
- secretory granule localization
- transcytosis
- small GTPase mediated signal transduction
- Golgi vesicle docking
- intracellular protein transport
- vesicle fusion with Golgi apparatus
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- microtubule organizing center
- membrane
- ER to Golgi transport vesicle membrane
- cytosol
- endoplasmic reticulum
- Golgi apparatus
- Golgi membrane
- transport vesicle
- Golgi stack
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- cadherin binding