Txn2 Gene Summary [Mouse]
Predicted to contribute to peptide-methionine (R)-S-oxide reductase activity; peptide-methionine (S)-S-oxide reductase activity; and protein-disulfide reductase activity. Predicted to be involved in cell redox homeostasis. Located in mitochondrion. Is expressed in future spinal cord; heart; heart apex; spinal cord; and spinal cord white matter. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 29. Orthologous to human TXN2 (thioredoxin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Txn2 |
| Official Name | thioredoxin 2 [Source:MGI Symbol;Acc:MGI:1929468] |
| Ensembl ID | ENSMUSG00000005354 |
| Bio databases IDs | |
| Aliases | thioredoxin 2 |
| Synonyms | 2510006J11Rik, COXPD29, MTRX, MT-TRX, thioredoxin 2, TRX2, TXN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Txn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- thioredoxin-like domain
- catalytic domain
- protein disulfide oxidoreductase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- sulfur group:disulfide oxidoreductase
- enzyme
- protein binding
- protein-methionine-S-oxide reductase
- thioredoxin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- hypertension
- combined oxidative phosphorylation deficiency 29
role in cell
- cell death
- apoptosis
- proliferation
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Mitochondria
- mitochondrial matrix
- nucleoli
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Txn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- response to glucose stimulus
- response to hypoxia
- cellular response to nutrient levels
- cell redox homeostasis
- response to axon injury
- response to organic cyclic compound
- response to xenobiotic stimulus
- response to hormone stimulus
Cellular Component
Where in the cell the gene product is active
- dendrite
- mitochondrial matrix
- mitochondrion
- neuronal cell body
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein disulfide oxidoreductase activity
- protein binding
- peptide-methionine-(S)-S-oxide reductase activity
- peptide-methionine (R)-S-oxide reductase activity