Evx1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryo development; generation of neurons; and positive regulation of transcription by RNA polymerase II. Located in axon and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; genitourinary system; and limb bud. Orthologous to human EVX1 (even-skipped homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Evx1 |
| Official Name | even-skipped homeobox 1 [Source:MGI Symbol;Acc:MGI:95461] |
| Ensembl ID | ENSMUSG00000005503 |
| Bio databases IDs | |
| Aliases | even-skipped homeobox 1 |
| Synonyms | even-skipped homeobox 1, LOC100911889, NEWGENE 1565788, RGD1565788 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Evx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- transcription factor activity
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Evx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development ending in birth or egg hatching
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- neuronal cell body
- chromatin
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity