Mtf2 Gene Summary [Mouse]
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and methylated histone binding activity. Involved in several processes, including epigenetic regulation of gene expression; segment specification; and stem cell population maintenance. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of ESC/E(Z) complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human MTF2 (metal response element binding transcription factor 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mtf2 |
| Official Name | metal response element binding transcription factor 2 [Source:MGI Symbol;Acc:MGI:105050] |
| Ensembl ID | ENSMUSG00000029267 |
| Bio databases IDs | |
| Aliases | metal response element binding transcription factor 2 |
| Synonyms | 9230112N11Rik, C76717, dJ976O13.2, M96, metal response element binding transcription factor 2, PCL2, RGD1304727, TDRD19A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mtf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Polycomb-like MTF2 factor 2
- PHD zinc finger
- histone binding
- transcription regulator
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- double-stranded DNA binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- PHD finger superfamily
- Tudor domain superfamily
- Jumonji domain-containing protein 2A Tudor domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Parkinson disease
role in cell
- differentiation
- binding in
- repression in
- replicative senescence
- upregulation in
- maintenance
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mtf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- stem cell maintenance
- stem cell differentiation
- regulation of gene expression, epigenetic
- segment specification
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- ESC/E(Z) complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- DNA binding
- metal ion binding
- methylated histone residue binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- chromatin binding