Eif4g2 Gene Summary [Mouse]
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Eif4g2 |
| Official Name | eukaryotic translation initiation factor 4, gamma 2 [Source:MGI Symbol;Acc:MGI:109207] |
| Ensembl ID | ENSMUSG00000005610 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4, gamma 2 |
| Synonyms | AAG1, DAP-5, E130105L11RIK, eukaryotic translation initiation factor 4 gamma 2, eukaryotic translation initiation factor 4, gamma 2, eukaryotic translation initiation factor 4 γ 2, eukaryotic translation initiation factor 4, γ 2, IF4G2, NAT1, Natm1, P97 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif4g2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- MA3 domain
- MIF4G domain
- eIF4-gamma/eIF5/eIF2-epsilon
- translation initiation factor
- protein binding
- C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
- translation regulator
Pathways
Biological processes and signaling networks where the Eif4g2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- growth failure
- gastrulation failure
role in cell
- phosphorylation in
- expression in
- cell death
- apoptosis
- growth
- induction in
- outgrowth
- outgrowth in
- cell cycle progression
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- axons
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif4g2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- positive regulation of cell growth
- cell death
- positive regulation of translation
- negative regulation of autophagy
- positive regulation of dendritic spine development
- macromolecule biosynthetic process
- positive regulation of axon extension
- regulation of cell cycle
- regulation of translational initiation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- adherens junction
- eukaryotic translation initiation factor 4F complex
- membrane
- cytosol
- axon
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- protein binding
- cadherin binding
- mRNA binding
- translation factor activity, nucleic acid binding