Dnase1 Gene Summary [Mouse]
Enables deoxyribonuclease I activity. Involved in several processes, including DNA catabolic process; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in extracellular region; nuclear envelope; and zymogen granule. Predicted to be active in nucleus. Is expressed in jejunum; metanephros; and tongue. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnase1 |
| Official Name | deoxyribonuclease I [Source:MGI Symbol;Acc:MGI:103157] |
| Ensembl ID | ENSMUSG00000005980 |
| Bio databases IDs | |
| Aliases | deoxyribonuclease I |
| Synonyms | Deoxyribonuclease, deoxyribonuclease 1, deoxyribonuclease I, DNaseI, DNL1, dornase alfa, dornase alpha, dornase α, DRNI, recombinantDNAse, rhDNase, Serum Dnase I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dnase1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin-binding domain
- DNase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- active site
- enzyme
- protein binding
- deoxyribonuclease I
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- infection
- polycystic kidney disease
- systemic lupus erythematosus
- fibrosis
- lupus erythematosus
- non-insulin-dependent diabetes mellitus
- cystic fibrosis
- glomerulonephritis
role in cell
- activation
- expression in
- survival
- binding in
- quantity
- formation
- apoptosis
- release
- removal
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- Cytoplasm
- nuclear envelope
- zymogen granules
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dnase1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neutrophil mediated cytotoxicity
- DNA catabolic process
- apoptotic process
- neutrophil activation involved in immune response
- regulation of acute inflammatory response
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- extracellular vesicular exosome
- extracellular region
- zymogen granule
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- actin binding
- deoxyribonuclease I activity