Napa Gene Summary [Mouse]
Enables syntaxin binding activity. Involved in regulation of synaptic vesicle priming and synaptic vesicle priming. Acts upstream of or within several processes, including SNARE complex disassembly; apical protein localization; and nervous system development. Located in myelin sheath. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is active in glutamatergic synapse. Is expressed in central nervous system; peripheral nervous system ganglion; and retina. Orthologous to human NAPA (NSF attachment protein alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Napa |
| Official Name | N-ethylmaleimide sensitive fusion protein attachment protein alpha [Source:MGI Symbol;Acc:MGI:104563] |
| Ensembl ID | ENSMUSG00000006024 |
| Bio databases IDs | |
| Aliases | N-ethylmaleimide sensitive fusion protein attachment protein alpha |
| Synonyms | 1500039N14Rik, alpha-SNAP, a-SNAP, hyh, N-ethylmaleimide sensitive fusion protein attachment protein alpha, N-ethylmaleimide sensitive fusion protein attachment protein α, NSF, NSF attachment protein alpha, NSF attachment protein α, RA81, SNAPA, SNAP-alpha, SNAP-α, SNARE, soluble n ethyl maleimide sensitive factor attachment protein α, α-SNAP, α-soluble nsf attachment |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Napa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- binding protein
- Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
- protein binding
- transporter
- syntaxin binding
- Soluble NSF attachment protein, SNAP
Pathways
Biological processes and signaling networks where the Napa gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- hydrocephaly with hop gait
- Huntington disease
- atopic dermatitis
role in cell
- expression in
- apoptosis
- phosphorylation in
- cell death
- differentiation
- docking
- fusion
- exocytosis
- detachment
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- high-density microsomal fractions
- myelin enriched fraction
- Golgi-enriched fraction
- low-density microsomal fraction
- detergent-insoluble fractions
- membrane fraction
- glutaminergic synapse
- presynaptic regions
- postsynaptic region
- intracellular membranes
- Plasma Membrane
- vesicles
- Golgi Apparatus
- granules
- cytosol
- presynaptic membrane
- Golgi membrane
- synaptic vesicles
- neuromuscular junctions
- dendritic shafts
- phagosomes
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Napa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
- regulation of synaptic vesicle priming
- synaptic vesicle priming
- neuron differentiation
- apical protein localization
- SNARE complex disassembly
- intra-Golgi vesicle-mediated transport
- brain development
- intracellular protein transport
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- synaptobrevin 2-SNAP-25-syntaxin-1a complex
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- soluble NSF attachment protein activity
- SNARE binding