Inpp5k Gene Summary [Mouse]
Enables inositol bisphosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and vasopressin receptor activity. Involved in several processes, including cellular response to cAMP; negative regulation of metabolic process; and negative regulation of signal transduction. Acts upstream of or within in utero embryonic development and response to insulin. Located in endoplasmic reticulum. Is expressed in central nervous system and skeletal musculature. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Inpp5k |
| Official Name | inositol polyphosphate 5-phosphatase K [Source:MGI Symbol;Acc:MGI:1194899] |
| Ensembl ID | ENSMUSG00000006127 |
| Bio databases IDs | |
| Aliases | inositol polyphosphate 5-phosphatase K |
| Synonyms | C62, inositol polyphosphate-5-phosphatase K, MDCCAID, PPS, SKIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Inpp5k often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SKICH domain
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase
- inositol trisphosphate phosphatase
- vasopressin receptor
- inositol bisphosphate phosphatase
- inositol-polyphosphate 5-phosphatase
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- SKIP carboxyl homology domain
- phosphatase
- protein binding
- phosphoinositide 5-phosphatase
Pathways
Biological processes and signaling networks where the Inpp5k gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- obesity
- hereditary disorder
- congenital muscular dystrophy with cataracts and intellectual disability
- survival
- chronic lymphocytic leukemia
role in cell
- expression in
- phosphorylation in
- proliferation
- transcription in
- growth
- migration
- response by
- number
- differentiation
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- membrane ruffles
- trans Golgi network
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Inpp5k gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein targeting to membrane
- negative regulation by host of viral transcription
- positive regulation of renal water transport
- negative regulation of retroviral genome replication
- negative regulation of MAP kinase activity
- phosphatidylinositol biosynthetic process
- negative regulation of protein kinase activity
- phosphatidylinositol dephosphorylation
- cellular response to insulin stimulus
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- in utero embryonic development
- negative regulation of peptidyl-serine phosphorylation
- negative regulation of calcium ion transport
- cellular response to tumor necrosis factor
- dephosphorylation
- positive regulation of urine volume
- G-protein coupled receptor signaling pathway
- negative regulation of glycogen biosynthetic process
- negative regulation of insulin receptor signaling pathway
- negative regulation of stress fiber assembly
- negative regulation of glucose transport
- ruffle assembly
- regulation of glycogen biosynthetic process
- negative regulation of peptidyl-threonine phosphorylation
- negative regulation of protein phosphorylation
- cellular response to epidermal growth factor stimulus
- cellular response to cAMP
- glucose homeostasis
- negative regulation of dephosphorylation
- cellular response to hormone stimulus
- actin cytoskeleton organization
- protein localization in plasma membrane
- negative regulation of protein kinase B signaling cascade
- negative regulation of glycogen (starch) synthase activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- trans-Golgi network
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- ruffle
- cytosol
- ruffle membrane
- endoplasmic reticulum
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
- phosphatidylinositol phosphate 5-phosphatase activity
- phosphatidylinositol trisphosphate phosphatase activity
- vasopressin receptor activity
- lipid phosphatase activity
- inositol-polyphosphate 5-phosphatase activity
- protein binding
- inositol trisphosphate phosphatase activity
- phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
- inositol-1,4,5-trisphosphate 5-phosphatase activity
- inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
- inositol bisphosphate phosphatase activity