Usp47 Gene Summary [Mouse]
Predicted to enable WD40-repeat domain binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytosol and nucleus. Orthologous to human USP47 (ubiquitin specific peptidase 47). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp47 |
| Official Name | ubiquitin specific peptidase 47 [Source:MGI Symbol;Acc:MGI:1922246] |
| Ensembl ID | ENSMUSG00000059263 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 47 |
| Synonyms | 4930502N04Rik, A630020C16RIK, TRFP, ubiquitin specific peptidase 47, USP47 isoform 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp47 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein domain specific binding
- Ubiquitin carboxyl-terminal hydrolase 47 C-terminal
- protein binding
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp47 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- insomnia
- dextran sodium sulfate-induced colitis
role in cell
- expression in
- quantity
- activation in
- proliferation
- growth
- growth in
- phosphorylation in
- cell death
- translation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp47 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- monoubiquitinated protein deubiquitination
- base-excision repair
- positive regulation of canonical Wnt receptor signaling pathway
- DNA damage response, signal transduction resulting in induction of apoptosis
- response to xenobiotic stimulus
- response to DNA damage stimulus
- positive regulation of cell growth
- negative regulation of transcription, DNA-dependent
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of apoptotic process
- proteolysis
- cellular response to UV
- negative regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- WD40-repeat domain binding