Ggt5 Gene Summary [Mouse]
Enables leukotriene-C(4) hydrolase. Acts upstream of or within several processes, including inflammatory response; leukotriene D4 biosynthetic process; and lymphocyte migration. Located in plasma membrane. Orthologous to human GGT5 (gamma-glutamyltransferase 5). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ggt5 |
| Official Name | gamma-glutamyltransferase 5 [Source:MGI Symbol;Acc:MGI:1346063] |
| Ensembl ID | ENSMUSG00000006344 |
| Bio databases IDs | |
| Aliases | gamma-glutamyltransferase 5 |
| Synonyms | gamma-glutamyltransferase 5, gamma GLUTAMYLTRANSFERASE LIKE ACTIVITY1, GGL, Ggta1, GGTLA1, GGT-REL, γ glutamyl leukotrienase, γ-glutamyltransferase 5, γ GLUTAMYLTRANSFERASE LIKE ACTIVITY1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ggt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidyltransferase
- Gamma-glutamyltranspeptidase
- omega peptidase
- peptidase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- COVID-19
- androgenic alopecia
- hepatitis B virus-related hepatocellular carcinoma
- acute inflammation
- growth failure
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- chronic sinusitis
regulates
- leukotriene C4
- glutathione
- fatty acid
- leukotriene D4
- S-decylglutathione
- amino acids
role in cell
- growth
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ggt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- proteolysis
- glutathione biosynthetic process
- cellular amino acid metabolic process
- glutathione catabolic process
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- peptidyltransferase activity