Slc1a4

Enables L-aspartate transmembrane transporter activity; L-serine transmembrane transporter activity; and neutral L-amino acid transmembrane transporter activity. Involved in L-aspartate import across plasma membrane. Acts upstream of or within serine import across plasma membrane. Located in intermediate filament. Is expressed in several structures, including central nervous system; dorsal root ganglion; lung; nose; and thymus primordium. Used to study spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Human ortholog(s) of this gene implicated in spastic tetraplegia, thin corpus callosum, and progressive microcephaly. Orthologous to human SLC1A4 (solute carrier family 1 member 4). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc1a4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Slc1a4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc1a4 gene, providing context for its role in the cell.