Mpl Gene Summary [Mouse]
Predicted to enable thrombopoietin receptor activity. Involved in thrombopoietin-mediated signaling pathway. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of stem cell division. Predicted to be located in several cellular components, including Golgi apparatus; neuronal cell body; and nuclear membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including brain; hemolymphoid system; mesenchyme derived from splanchnopleure; spinal cord; and vestibulo-cochlear ganglion. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia 1; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mpl |
| Official Name | myeloproliferative leukemia virus oncogene [Source:MGI Symbol;Acc:MGI:97076] |
| Ensembl ID | ENSMUSG00000006389 |
| Bio databases IDs | |
| Aliases | myeloproliferative leukemia virus oncogene |
| Synonyms | CD110, C-MPL, hlb219, MPL proto-oncogene, thrombopoietin receptor, MPLV, myeloproliferative leukaemia virus oncogene, myeloproliferative leukemia virus oncogene, THCYT2, THPOR, TPO-R, TPO receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mpl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein binding
- Fibronectin type 3 domain
- Box I domain
- Box II domain
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- membrane-proximal domain
- cytokine receptor
- transmembrane receptor
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Mpl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myelodysplastic syndrome
- acute myeloid leukemia
- chronic hepatitis C
- tumorigenesis
- chemotherapy induced thrombocytopenia
- primary immune thrombocytopenia
- chronic primary immune thrombocytopenia
- essential thrombocythemia
- congenital amegakaryocytic thrombocytopenia
- immune thrombocytopenia
role in cell
- activation in
- colony formation
- expression in
- apoptosis
- proliferation
- formation
- phosphorylation in
- growth
- signaling in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- Golgi Apparatus
- nuclear envelope
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mpl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lymphocyte proliferation
- immunoglobulin mediated immune response
- monocyte homeostasis
- thrombopoietin-mediated signaling pathway
- cellular response to hypoxia
- neutrophil homeostasis
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- external side of plasma membrane
- Golgi apparatus
- neuronal cell body
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- thrombopoietin receptor activity