Tcf23 Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription regulator inhibitor activity. Involved in negative regulation of muscle cell differentiation and negative regulation of transcription by RNA polymerase II. Located in euchromatin. Is expressed in central nervous system and genitourinary system. Orthologous to human TCF23 (transcription factor 23). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tcf23 |
| Official Name | transcription factor 23 [Source:MGI Symbol;Acc:MGI:1934960] |
| Ensembl ID | ENSMUSG00000006642 |
| Bio databases IDs | |
| Aliases | transcription factor 23 |
| Synonyms | 2010002O16Rik, bHLHa24, LOC100364945, LOC684101, OUT, transcription factor 23 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tcf23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- transcription factor binding
- protein binding
- Helix-loop-helix DNA-binding domain
Pathways
Biological processes and signaling networks where the Tcf23 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tcf23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- muscle organ development
- negative regulation of muscle cell differentiation
- positive regulation of gene expression
- cell differentiation
- decidualization
- developmental process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity