Klf5 Gene Summary [Mouse]
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; MRF binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of DNA-templated transcription; and skeletal muscle tissue regeneration. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; gut; respiratory system; and sensory organ. Orthologous to human KLF5 (KLF transcription factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klf5 |
| Official Name | Kruppel-like factor 5 [Source:MGI Symbol;Acc:MGI:1338056] |
| Ensembl ID | ENSMUSG00000005148 |
| Bio databases IDs | |
| Aliases | Kruppel-like factor 5 |
| Synonyms | 4930520J07Rik, BTEB2, CKLF, IKLF, KLF transcription factor 5, Kruppel-like factor 5, Kruppel-like transcription factor 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- zinc finger DNA binding domain
- activation domain
- transcription regulator
- acetylation site
- Cdc-phosphodegrons
- DNA binding domain
- nucleic acid binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Klf5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic pancreatitis
- schizophrenia
- obesity
- chronic obstructive pulmonary disease
- hypertension
- ulcerative colitis
- open-angle glaucoma
- neoplastic cell transformation
- colorectal cancer
role in cell
- apoptosis
- expression in
- production in
- proliferation
- molecular cleavage in
- activation in
- cell viability
- invasion by
- migration
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Golgi Apparatus
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- myotube differentiation involved in skeletal muscle regeneration
- angiogenesis
- satellite cell differentiation
- microvillus assembly
- positive regulation of fat cell differentiation
- satellite cell activation involved in skeletal muscle regeneration
- positive regulation of transcription from RNA polymerase II promoter
- intestinal epithelial cell development
- regulation of microvillus assembly
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- intracellular membrane-bounded organelle
- Golgi apparatus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- MRF binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity