Acot13 Gene Summary [Mouse]
Enables fatty acyl-CoA hydrolase activity. Involved in negative regulation of cold-induced thermogenesis. Located in mitochondrial matrix. Is expressed in chondrocranium; hindgut; and midgut. Orthologous to human ACOT13 (acyl-CoA thioesterase 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acot13 |
| Official Name | acyl-CoA thioesterase 13 [Source:MGI Symbol;Acc:MGI:1914084] |
| Ensembl ID | ENSMUSG00000006717 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 13 |
| Synonyms | 0610006O17Rik, ACO13, acyl-CoA thioesterase 13, HT012, PNAS-27, THEM2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acot13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thioesterase superfamily
- hot_dog
- enzyme
- protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- COVID-19
- allergic rhinitis
- prostate cancer
- weight gain
- microvesicular hepatic steatosis
- coronary artery disease
- hyperactive behavior
phenotypes
- abnormal adaptive thermogenesis
- abnormal circadian temperature homeostasis
- abnormal eating behavior
- abnormal enzyme/coenzyme activity
- abnormal feces composition
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal lipid level
- decreased basal metabolism
- decreased body weight
- decreased brown fat cell lipid droplet size
- decreased circulating free fatty acid level
- decreased circulating ketone body level
- decreased epididymal fat pad weight
- decreased food intake
- decreased liver cholesterol level
- decreased liver triglyceride level
- decreased oxygen consumption
- decreased respiratory quotient
- decreased susceptibility to hepatic steatosis
- decreased white adipose tissue amount
- hyperactivity
- hypoactivity
- improved glucose tolerance
- increased body weight
- increased core body temperature
- increased energy expenditure
- increased food intake
- increased lean body mass
- increased oxygen consumption
- increased respiratory quotient
role in cell
- size
- expression in
- consumption in
- hydrolysis in
- ultrastructure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acot13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- spindle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- acyl-CoA hydrolase activity