Nod1 Gene Summary [Mouse]
Enables pattern recognition receptor activity and peptidoglycan binding activity. Involved in several processes, including nucleotide-binding activity oligomerization domain containing 1 signaling pathway; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of dendritic cell antigen processing and presentation. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of cytokine production; and positive regulation of xenophagy. Located in phagocytic vesicle. Is expressed in several structures, including alimentary system; autopod; brain; olfactory epithelium; and urinary system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human NOD1 (nucleotide binding oligomerization domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nod1 |
| Official Name | nucleotide-binding oligomerization domain containing 1 [Source:MGI Symbol;Acc:MGI:1341839] |
| Ensembl ID | ENSMUSG00000038058 |
| Bio databases IDs | |
| Aliases | nucleotide-binding oligomerization domain containing 1 |
| Synonyms | C230079P11, CARD4, CASPASE RECRUITMENT domain family 4, CLR7.1, F830007N14Rik, hNod1, mNod1, NLRC1, nucleotide-binding oligomerization domain containing 1, RGD1562269 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nod1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- NLRC4 helical domain HD2
- NOD2 winged helix domain
- protein phosphatase 1 regulatory subunit 42
- signaling receptor activity
- ubiquitin binding
- caspase activator
- protein binding
- NACHT domain
- identical protein binding
- P-loop
- nucleotide-binding domain
- Caspase recruitment domain
- leucine-rich repeat
- binding protein
- Leucine rich repeat, ribonuclease inhibitor type
- protein homodimerization
- peptidoglycan binding
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Nod1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sepsis
- metastasis
- Crohn disease
- pneumonia
- neoplasia
- refractive error
- atherosclerosis
- osteoarthritis
- shock response
- preeclampsia
role in cell
- phosphorylation in
- expression in
- production in
- activation in
- activation
- quantity
- phagocytosis by
- migration
- proliferation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- cytosol
- apical cell surfaces
- basolateral membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nod1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of biotic stimulus
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- JNK cascade
- pattern recognition receptor signaling pathway
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of macrophage cytokine production
- inflammatory response
- apoptotic process
- positive regulation of tumor necrosis factor production
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- nucleotide-binding oligomerization domain containing 1 signaling pathway
- intracellular signal transduction
- defense response to Gram-positive bacterium
- stress-activated MAPK cascade
- defense response to Gram-negative bacterium
- signal transduction
- defense response
- defense response to bacterium
- ERK1 and ERK2 cascade
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of interleukin-8 production
- positive regulation of JNK cascade
- innate immune response
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of apoptotic process
- positive regulation of dendritic cell antigen processing and presentation
- detection of bacterium
- cellular response to muramyl dipeptide
- positive regulation of interleukin-6 production
- positive regulation of stress-activated MAPK cascade
- positive regulation of interleukin-1 beta production
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- phagocytic vesicle
- cytosol
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- peptidoglycan binding
- identical protein binding
- protein binding
- protein homodimerization activity
- ubiquitin binding
- CARD domain binding
- cysteine-type endopeptidase activator activity involved in apoptotic process