ACOT13 Gene Summary [Human]
This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009]
Details
| Type | Protein Coding |
| Official Symbol | ACOT13 |
| Official Name | acyl-CoA thioesterase 13 [Source:HGNC Symbol;Acc:HGNC:20999] |
| Ensembl ID | ENSG00000112304 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 13 |
| Synonyms | 0610006O17Rik, ACO13, acyl-CoA thioesterase 13, HT012, PNAS-27, THEM2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACOT13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thioesterase superfamily
- hot_dog
- enzyme
- protein binding
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- COVID-19
- allergic rhinitis
- prostate cancer
- weight gain
- microvesicular hepatic steatosis
- coronary artery disease
- hyperactive behavior
role in cell
- size
- expression in
- consumption in
- hydrolysis in
- ultrastructure
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACOT13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- spindle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- acyl-CoA hydrolase activity