Tph2 Gene Summary [Mouse]
Enables tryptophan 5-monooxygenase activity. Predicted to act upstream of or within serotonin biosynthetic process from tryptophan. Located in neuron projection. Is expressed in several structures, including aorta-gonad-mesonephros; germ cell of ovary; nervous system; retina; and tongue. Used to study melancholic depression. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; anxiety disorder (multiple); autistic disorder; and drug dependence (multiple). Orthologous to human TPH2 (tryptophan hydroxylase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tph2 |
| Official Name | tryptophan hydroxylase 2 [Source:MGI Symbol;Acc:MGI:2651811] |
| Ensembl ID | ENSMUSG00000006764 |
| Bio databases IDs | |
| Aliases | tryptophan hydroxylase 2 |
| Synonyms | ADHD7, AU043594, NTPH, Tryptophan hydroxylase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tph2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arom_aa_hydroxylase
- tryptophan 5-monooxygenase, tetrameric
- tyrosine 3-monooxygenase, tetrameric
- phenylalanine-4-hydroxylase, tetrameric form
- enzyme
- tryptophan 5-monooxygenase
- ACT domain
- Biopterin-dependent aromatic amino acid hydroxylase
Pathways
Biological processes and signaling networks where the Tph2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- starvation
- metabolic syndrome X
- mechanical hyperalgesia
- major affective disorder type 1
- major depression
- phenylketonuria
- tetrahydrobiopterin deficiency
- peripartum depression
- dermatological disorder
phenotypes
- abnormal autonomic nervous system physiology
- abnormal circadian regulation of heart rate
- abnormal circadian regulation of systemic arterial blood pressure
- abnormal emotion/affect behavior
- abnormal hippocampus morphology
- abnormal maternal nurturing
- abnormal mating preference
- abnormal nervous system electrophysiology
- abnormal paraventricular hypothalamic nucleus morphology
- abnormal pup retrieval
- abnormal response to novel object
- abnormal serotonergic neuron morphology
- abnormal serotonin level
- abnormal skin condition
- abnormal sleep pattern
- abnormal suprachiasmatic nucleus morphology
- decreased body length
- decreased body size
- decreased body weight
- decreased circulating insulin-like growth factor I level
- decreased coping response
- decreased pulmonary respiratory rate
- decreased serotonin level
- impaired adaptive thermogenesis
- increased aggression
- increased aggression towards females
- increased aggression towards males
- increased anxiety-related response
- increased core body temperature
- induced hyperactivity
- no abnormal phenotype detected
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
- pup cannibalization
- weakness
role in cell
- quantity
- activation
- density
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- neurites
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tph2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- serotonin biosynthetic process
- aromatic amino acid family metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- neuron projection
Molecular Function
What the gene product does at the molecular level
- iron ion binding
- tryptophan 5-monooxygenase activity