Elk3 Gene Summary [Mouse]
Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within angiogenesis; regulation of DNA-templated transcription; and wound healing. Located in nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and heart. Used to study congenital chylothorax. Orthologous to human ELK3 (ETS transcription factor ELK3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elk3 |
| Official Name | ELK3, member of ETS oncogene family [Source:MGI Symbol;Acc:MGI:101762] |
| Ensembl ID | ENSMUSG00000008398 |
| Bio databases IDs | |
| Aliases | ELK3, member of ETS oncogene family |
| Synonyms | D430049E23Rik, ELK3, member of ETS oncogene family, Epr, ERP, Etrp, ETS transcription factor ELK3, FLJ22425, NET, SAP-2, SRF accessory protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elk3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- net inhibitory domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- A-box
- transcription regulator
- DNA binding domain
- nucleic acid binding
- C-box domain
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- C-terminal-binding protein interaction domain
- double-stranded DNA binding
- Ets-domain
- Box B domain
- transcription factor activity
- CAD domain
Pathways
Biological processes and signaling networks where the Elk3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma
- systemic lupus erythematosus
- organismal death
- metastasis
- precursor B-cell acute lymphoblastic leukemia
- glioma
- glioma formation
- glioblastoma cancer
- dyspnea
role in cell
- expression in
- apoptosis
- proliferation
- activation in
- production in
- migration
- damage in
- adhesion
- transcription in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Mitochondria
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elk3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- wound healing
- signal transduction
- angiogenesis
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- purine-rich negative regulatory element binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity