Cmas Gene Summary [Mouse]
Enables N-acylneuraminate cytidylyltransferase activity. Involved in CMP-N-acetylneuraminate biosynthetic process and N-acetylneuraminate metabolic process. Is active in nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; liver; nervous system; and sensory organ. Used to study focal segmental glomerulosclerosis. Orthologous to human CMAS (cytidine monophosphate N-acetylneuraminic acid synthetase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cmas |
| Official Name | cytidine monophospho-N-acetylneuraminic acid synthetase [Source:MGI Symbol;Acc:MGI:1337124] |
| Ensembl ID | ENSMUSG00000030282 |
| Bio databases IDs | |
| Aliases | cytidine monophospho-N-acetylneuraminic acid synthetase |
| Synonyms | CMPNeu5Ac, CSS, cytidine monophosphate N-acetylneuraminic acid synthetase, cytidine monophospho-N-acetylneuraminic acid synthetase, D6Bwg0250e |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cmas often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family
- N-acylneuraminate cytidylyltransferase
- Cytidylyltransferase
- acylneuraminate cytidylyltransferase
- enzyme
- glycosyltransferase family A
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- infection by Enterovirus D68
role in cell
- expression in
- number
- phagocytosis by
- production in
- sialylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cmas gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-acetylneuraminate metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- N-acylneuraminate cytidylyltransferase activity