Hira Gene Summary [Mouse]
Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity and histone binding activity. Predicted to contribute to nucleosome binding activity. Acts upstream of or within gastrulation; muscle cell differentiation; and osteoblast differentiation. Located in chromatin. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; limb bud; and sensory organ. Orthologous to human HIRA (histone cell cycle regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hira |
| Official Name | histone cell cycle regulator [Source:MGI Symbol;Acc:MGI:99430] |
| Ensembl ID | ENSMUSG00000022702 |
| Bio databases IDs | |
| Aliases | histone cell cycle regulator |
| Synonyms | AA138857, D16Ertd95e, DGCR1, Gm15797, histone cell cycle regulator, LOC100911837, TUP1, TUPLE1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hira often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- WD40 repeats
- B domain
- transcription co-repressor
- TUP1-like enhancer of split
- WD domain, G-beta repeat
- transcription factor binding
- WD40
- protein binding
- glutamine-rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- choroidal neovascularization
- growth failure
- edema
- chorioallantoic membrane fusion failure
- gastrulation failure
- failure of heart looping
role in cell
- expression in
- proliferation
- growth
- phosphorylation in
- activation in
- assembly
- differentiation
- induction in
- assembly in
- reactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear foci
- nucleoplasm
- nuclear bodies
- nuclear speckles
- PML nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hira gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- transcription, DNA-dependent
- muscle cell differentiation
- osteoblast differentiation
- anatomical structure morphogenesis
- nucleosome assembly
- regulation of transcription from RNA polymerase II promoter
- gastrulation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- PML body
- HIR complex
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity
- histone binding
- nucleosome binding