Rdh13 Gene Summary [Mouse]
Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Acts upstream of or within eye photoreceptor cell development; response to high light intensity; and retina layer formation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human RDH13 (retinol dehydrogenase 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Rdh13 |
| Official Name | retinol dehydrogenase 13 (all-trans and 9-cis) [Source:MGI Symbol;Acc:MGI:1918732] |
| Ensembl ID | ENSMUSG00000008435 |
| Bio databases IDs | |
| Aliases | retinol dehydrogenase 13 (all-trans and 9-cis) |
| Synonyms | 8430425D21Rik, retinol dehydrogenase 13, retinol dehydrogenase 13 (all-trans and 9-cis), SDR7C3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rdh13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- enzyme
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Rdh13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rdh13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to high light intensity
- retinol metabolic process
- retina layer formation
- eye photoreceptor cell development
- retinal metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADP-retinol dehydrogenase activity