Alpi Gene Summary [Mouse]
Predicted to enable several functions, including alkaline phosphatase activity; metal ion binding activity; and protein homodimerization activity. Acts upstream of or within cellular response to BMP stimulus. Predicted to be located in external side of plasma membrane. Predicted to be active in extracellular space and plasma membrane. Is expressed in intestine; palatal shelf mesenchyme; and testis. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell) and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alpi |
| Official Name | alkaline phosphatase, intestinal [Source:MGI Symbol;Acc:MGI:1924018] |
| Ensembl ID | ENSMUSG00000079440 |
| Bio databases IDs | |
| Aliases | alkaline phosphatase, intestinal |
| Synonyms | 2010001C14RIK, Adult Intestinal Alkaline Phosphatase, Akp6, alkaline phosphatase, intestinal, Alppl2, Fetal Intestinal Alkaline Phosphatase, Fetal Intestinal-Type Alkaline Phosphatase, foetal Intestinal Alkaline Phosphatase, foetal Intestinal-Type Alkaline Phosphatase, Gcap, gIAP, IAP, Intestinal Form of Alkaline Phosphatase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alpi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- alkaline phosphatase
- Alkaline phosphatase homologues
- protease binding
- zinc ion binding
- phosphatase
- protein homodimerization
- protein binding
- magnesium ion binding
Pathways
Biological processes and signaling networks where the Alpi gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- zinc deficiency
- HIV infection
- undernutrition
- pneumonia
- COVID-19
- liver neoplasia
- mineral deficiency
- morbid obesity
- sickle cell anemia
- very low birth weight
regulates
- coenzyme A
role in cell
- growth
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alpi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dephosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- zinc ion binding
- protein binding
- protease binding
- alkaline phosphatase activity