Slc39a12 Gene Summary [Mouse]
Enables zinc ion transmembrane transporter activity. Acts upstream of or within several processes, including regulation of microtubule polymerization; regulation of neuron projection development; and zinc ion import across plasma membrane. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in embryo mesenchyme; forelimb; and nervous system. Orthologous to human SLC39A12 (solute carrier family 39 member 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc39a12 |
| Official Name | solute carrier family 39 (zinc transporter), member 12 [Source:MGI Symbol;Acc:MGI:2139274] |
| Ensembl ID | ENSMUSG00000036949 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 (zinc transporter), member 12 |
| Synonyms | AW046938, bA570F3.1, Gm731, LZT-Hs8, solute carrier family 39 member 12, solute carrier family 39 (zinc transporter), member 12, ZIP-12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc39a12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZIP Zinc transporter
- Zinc transporter ZIP4 domain
- zinc ion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral arterial disease
- esophageal adenocarcinoma
- esophageal carcinoma formation
regulates
- CREB
- tubulin (family)
- superoxide
role in cell
- phosphorylation in
- activation in
- outgrowth
- development
- length
- function
- polymerization in
- function in
- carbonylation in
- neurite outgrowth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc39a12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural tube formation
- signal transduction
- zinc ion import
- regulation of microtubule polymerization
- regulation of neuron projection development
- bicarbonate transport
- cellular cation homeostasis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion transmembrane transporter activity