Apobec3 Gene Summary [Mouse]
Predicted to enable several functions, including cytidine deaminase activity; identical protein binding activity; and zinc ion binding activity. Involved in negative regulation of viral genome replication and transposable element silencing. Acts upstream of or within hematopoietic progenitor cell differentiation; regulation of defense response to virus; and regulation of viral life cycle. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to several human genes including APOBEC3B (apolipoprotein B mRNA editing enzyme catalytic subunit 3B); APOBEC3D (apolipoprotein B mRNA editing enzyme catalytic subunit 3D); and APOBEC3F (apolipoprotein B mRNA editing enzyme catalytic subunit 3F). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Apobec3 |
| Official Name | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 [Source:MGI Symbol;Acc:MGI:1933111] |
| Ensembl ID | ENSMUSG00000009585 |
| Bio databases IDs | |
| Aliases | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 |
| Synonyms | A3H, Apobec, Apobec3, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3, apolipoprotein B mRNA editing enzyme catalytic subunit 3H, ARP-10, Arp3, Cem15, D730005E14Rik, Gm20117, RFV3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Apobec3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- APOBEC2
- cytidine_deaminase-like
- APOBEC-like N-terminal domain
- enzyme
- protein binding
- APOBEC4-like -AID/APOBEC-deaminase
- APOBEC1
- identical protein binding
- Secreted Novel AID/APOBEC-like Deaminase 4
- RNA binding
- APOBEC3
- zinc ion binding
- cytidine deaminase
- Novel AID APOBEC clade 2
- Novel AID APOBEC clade 1
- APOBEC4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- polyglandular autoimmune syndrome type 1
- infection by Murine leukemia virus
role in cell
- expression in
- differentiation
- production in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Apobec3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA cytosine deamination
- negative regulation of retroviral genome replication
- negative regulation of transposition, RNA-mediated
- innate immune response
- clearance of foreign intracellular DNA
- defense response to virus
- cytidine deamination
- cytidine to uridine editing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA binding
- cytidine deaminase activity