Bcar1 Gene Summary [Mouse]

Predicted to enable protein domain specific binding activity and protein kinase binding activity. Involved in G protein-coupled receptor signaling pathway and platelet-derived growth factor receptor signaling pathway. Acts upstream of or within cell migration. Located in several cellular components, including actin cytoskeleton; focal adhesion; and lamellipodium. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast ductal carcinoma. Orthologous to human BCAR1 (BCAR1 scaffold protein, Cas family member). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Bcar1
Official Name
breast cancer anti-estrogen resistance 1 [Source:MGI Symbol;Acc:MGI:108091]
Ensembl ID
ENSMUSG00000031955
Bio databases IDs NCBI: 12927 Ensembl: ENSMUSG00000031955
Aliases breast cancer anti-estrogen resistance 1
Synonyms BCAR1 scaffold protein, Cas family member, breast cancer anti-estrogen resistance 1, CAS, CAS1, CASS1, CRKAS, LOC100131601, P130CAP, P130CAS
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bcar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • substrate domain
  • Src binding domain
  • protein kinase binding
  • catalytic domain
  • caspase cleavage site
  • protein domain specific binding
  • enzyme
  • protein binding
  • polyproline motif
  • proline rich domain
  • Src Homology 3 domain superfamily
  • FAT-like_CAS_C
  • YXXP domain
  • serine-rich region
  • YDXP motif
  • SR domain
  • helix-loop-helix domain
  • PR domain
  • Serine_rich_CAS
  • Serine rich protein interaction domain
  • tyrosine phosphorylation site
  • Crk-Associated Substrate C-terminal domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • pancreatic epithelial cancer
  • metastasis
  • diabetes mellitus
  • breast carcinoma
  • pancreatic carcinoma
  • open-angle glaucoma
  • hereditary breast and/or ovarian cancer
  • diffuse systemic sclerosis
  • growth failure
regulated by
  • dihydrotestosterone
  • EGF
  • EGFR
  • lipopolysaccharide
  • D-glucose
  • insulin
  • GRP
  • sphingosine-1-phosphate
  • PP2/AG1879 tyrosine kinase inhibitor
  • TGFB1
regulates
role in cell
  • expression in
  • transformation
  • growth
  • binding in
  • proliferation
  • number
  • formation in
  • migration
  • apoptosis
  • cell cycle progression

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • nuclear fraction
  • membrane fraction
  • ruffle
  • cell periphery
  • perinuclear region
  • cellular membrane
  • focal adhesions
  • podosomes
  • actin cytoskeleton
  • membrane skeleton
  • Plasma Membrane
  • cytosol
  • apical cytoplasm
  • growth cone
  • neurites
  • axons
  • lamellipodia
  • cytoskeletal fraction
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Bcar1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • G-protein coupled receptor signaling pathway
  • insulin receptor signaling pathway
  • epidermal growth factor receptor signaling pathway
  • actin filament organization
  • platelet-derived growth factor receptor signaling pathway
  • transmembrane receptor protein tyrosine kinase signaling pathway
  • regulation of apoptotic process
  • cell adhesion
  • cell chemotaxis
  • cell division
  • hepatocyte growth factor receptor signaling pathway
  • nerve growth factor receptor signaling pathway
  • antigen receptor-mediated signaling pathway
  • vascular endothelial growth factor receptor signaling pathway
  • integrin-mediated signaling pathway
  • regulation of cell growth
  • cellular response to hepatocyte growth factor stimulus
  • positive regulation of endothelial cell migration
  • cell migration
  • T cell receptor signaling pathway
  • positive regulation of cell migration
  • B cell receptor signaling pathway

Cellular Component

Where in the cell the gene product is active
  • focal adhesion
  • cytoplasm
  • ruffle
  • actin cytoskeleton
  • cytosol
  • axon
  • plasma membrane
  • lamellipodium

Molecular Function

What the gene product does at the molecular level
  • protein kinase binding
  • protein binding
  • SH3 domain binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.