G0s2 Gene Summary [Mouse]
Involved in positive regulation of cold-induced thermogenesis. Predicted to be active in mitochondrion. Is expressed in liver and trunk mesenchyme. Orthologous to human G0S2 (G0/G1 switch 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | G0s2 |
| Official Name | G0/G1 switch gene 2 [Source:MGI Symbol;Acc:MGI:1316737] |
| Ensembl ID | ENSMUSG00000009633 |
| Bio databases IDs | |
| Aliases | G0/G1 switch gene 2 |
| Synonyms | G0/G1 switch 2, G0/G1 switch gene 2, G0s2-like, GOS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse G0s2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G0/G1 switch protein 2
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- epithelial cancer
- psoriasis
- neoplastic cell transformation
- endometriosis
- obesity
- gout
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- infiltrating lobular breast carcinoma
role in cell
- proliferation
- expression in
- binding in
- apoptosis
- colony formation
- morphology
- lipolysis in
- size
- incorporation in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- lipid droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse G0s2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extrinsic apoptotic signaling pathway
- positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- lipid particle
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding