G0s2 Gene Summary [Mouse]
Involved in positive regulation of cold-induced thermogenesis. Predicted to be active in mitochondrion. Is expressed in liver and trunk mesenchyme. Orthologous to human G0S2 (G0/G1 switch 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | G0s2 |
| Official Name | G0/G1 switch gene 2 [Source:MGI Symbol;Acc:MGI:1316737] |
| Ensembl ID | ENSMUSG00000009633 |
| Bio databases IDs | |
| Aliases | G0/G1 switch gene 2 |
| Synonyms | G0/G1 switch 2, G0/G1 switch gene 2, G0s2-like, GOS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse G0s2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G0/G1 switch protein 2
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- epithelial cancer
- psoriasis
- neoplastic cell transformation
- endometriosis
- obesity
- gout
- rheumatoid arthritis
- non-insulin-dependent diabetes mellitus
- infiltrating lobular breast carcinoma
phenotypes
- abnormal brown adipose tissue thermogenesis
- abnormal fat cell differentiation
- abnormal lactation
- abnormal liver morphology
- abnormal white adipose tissue physiology
- absent gastric milk in neonates
- decreased abdominal adipose tissue amount
- decreased body fat mass
- decreased body weight
- decreased brown adipose tissue amount
- decreased circulating alanine transaminase level
- decreased circulating aspartate transaminase level
- decreased circulating insulin level
- decreased epididymal fat pad weight
- decreased gonadal fat pad weight
- decreased inguinal fat pad weight
- decreased kidney weight
- decreased liver triglyceride level
- decreased liver weight
- decreased omental fat pad weight
- decreased renal fat pad weight
- decreased respiratory quotient
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased susceptibility to induced hypothermia
- decreased total body fat amount
- decreased total fat pad weight
- decreased white adipose tissue mass
- decreased white fat cell size
- enhanced lipolysis
- hypoactivity
- improved glucose tolerance
- increased circulating free fatty acid level
- increased circulating glycerol level
- increased insulin sensitivity
- increased lean body mass
- increased oxygen consumption
- increased triglyceride lipase activity
- maternal effect
- slow postnatal weight gain
role in cell
- proliferation
- expression in
- binding in
- apoptosis
- colony formation
- morphology
- lipolysis in
- size
- incorporation in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- lipid droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse G0s2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- extrinsic apoptotic signaling pathway
- positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- lipid particle
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding