Mis18a Gene Summary [Mouse]
Enables protein-macromolecule adaptor activity. Acts upstream of or within chromatin remodeling; chromosome segregation; and protein localization to chromosome, centromeric region. Located in chromosome, centromeric region. Part of CENP-A recruiting complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human MIS18A (MIS18 kinetochore protein A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mis18a |
| Official Name | MIS18 kinetochore protein A [Source:MGI Symbol;Acc:MGI:1913828] |
| Ensembl ID | ENSMUSG00000022978 |
| Bio databases IDs | |
| Aliases | MIS18 kinetochore protein A |
| Synonyms | 2610039C10Rik, 2810018N07Rik, B28, C21orf45, C21orf46, FASP1, hMis18alpha, LOC105372778, MIS18alpha, MIS18 kinetochore protein A, RGD1310778 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mis18a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RLR_C_like
- protein binding activity, bridging
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mis18a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- chromosome segregation
- CenH3-containing nucleosome assembly at centromere
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding