Brf1 Gene Summary [Mouse]
Predicted to enable RNA polymerase III general transcription initiation factor activity and RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Acts upstream of or within regulation of mRNA stability. Predicted to be part of transcription factor TFIIIB complex and transcription preinitiation complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in cerebellofaciodental syndrome. Orthologous to human BRF1 (BRF1 general transcription factor IIIB subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brf1 |
| Official Name | BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit [Source:MGI Symbol;Acc:MGI:1919558] |
| Ensembl ID | ENSMUSG00000011158 |
| Bio databases IDs | |
| Aliases | BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit |
| Synonyms | 2510002F24Rik, BRF, BRF1 general transcription factor IIIB subunit, BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit, CFDS, GTF3B, hBRF, HEL-S-76p, mTFIIIB90, TAF3B2, TAF3C, TAFIII90, TF3B90, TfIIIB, TFIIIB90 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor TFIIB repeat
- protein repeat
- Brf1-like TBP-binding domain
- transcription regulator
- TFIIB zinc-binding
- Cyclin box fold superfamily
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- zinc finger domain
- ERK phosphorylation site
- HMG2 like domain
- ERK2 binding domain
Pathways
Biological processes and signaling networks where the Brf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cerebellofaciodental syndrome
- colorectal cancer
- ovarian neoplasia
- Huntington disease
- hereditary disorder
- lung neoplasm
- rectum neoplasm
- colorectal neoplasia
- global developmental delay with intellectual disability
regulates
- Collagen(s)
- DNA promoter
- DNA endogenous promoter
- CDKN1A
- Va1
- RNA polymerase iii
- Vai
- Va RNA I
- Eber2
- TP53
role in cell
- expression in
- apoptosis
- proliferation
- transcription in
- growth
- cell viability
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromosome
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription initiation from RNA polymerase III promoter
- rRNA transcription
- DNA-dependent transcriptional preinitiation complex assembly
- transcription initiation, DNA-dependent
- positive regulation of transcription from RNA polymerase III promoter
- tRNA transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIIIB complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- TBP-class protein binding
- core RNA polymerase III binding transcription factor activity
- RNA polymerase III type 3 promoter sequence-specific DNA binding