Flnb Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including cellular response to type II interferon; epithelial cell development; and skeletal muscle tissue development. Located in several cellular components, including brush border; focal adhesion; and stress fiber. Is expressed in several structures, including alimentary system; brain; facial prominence; sensory organ; and skeleton. Used to study spondylocarpotarsal synostosis syndrome. Human ortholog(s) of this gene implicated in Larsen syndrome; bone development disease (multiple); cleft palate; and spinal disease (multiple). Orthologous to human FLNB (filamin B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flnb |
| Official Name | filamin, beta [Source:MGI Symbol;Acc:MGI:2446089] |
| Ensembl ID | ENSMUSG00000025278 |
| Bio databases IDs | |
| Aliases | filamin, beta |
| Synonyms | ABP-278, ABP-280, AOI, Beta-filamin, FH1, Filamin 3, Filamin B, filamin, beta, Filamin homolog 1, filamin, β, FLN1L, FLN3, Flnb predicted, LOC100911261, LRS1, SCT, TABP, TAP, Thyroid autoantigen, β-filamin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flnb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- actin-binding domain
- Filamin/ABP280 repeat
- Calponin homology domain
- cytoplasmic domain
- calponin homology (CH) domain superfamily
- hinge domain
- immunoglobulin-like protein domain
- protein binding
- identical protein binding
- Filamin-type immunoglobulin domains
Pathways
Biological processes and signaling networks where the Flnb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- breast cancer
- atelosteogenesis
- Larsen syndrome
- atelosteogenesis type III
- Turner syndrome
- growth failure
- spondylocarpotarsal synostosis syndrome
- exophthalmos
- connective tissue disorder
role in cell
- apoptosis
- growth
- phosphorylation in
- activation in
- migration
- differentiation
- binding in
- internalization by
- function
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- focal adhesions
- actin cytoskeleton
- Plasma Membrane
- cytosol
- m-bands
- Z line
- actin stress fibers
- brush border
- cleavage furrow
- perikaryon
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flnb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- skeletal muscle tissue development
- epithelial cell morphogenesis
- cellular response to interferon-gamma
- actin cytoskeleton organization
- keratinocyte development
Cellular Component
Where in the cell the gene product is active
- phagocytic vesicle
- plasma membrane
- Z disc
- extracellular vesicular exosome
- focal adhesion
- brush border
- cytoplasm
- cell cortex
- membrane
- stress fiber
- actin cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- identical protein binding
- RNA binding
- protein binding
- actin binding
- cadherin binding