Mycl Gene Summary [Mouse]
This gene encodes a basic helix-loop-helix leucine zipper (bHLHZip) protein that heterodimerizes with another bHLHZip protein to drive transcription of targets important for proliferation, apoptosis and differentiation. Mice lacking this gene product show marked decrease in T-cell priming during bacterial and viral infections. In humans, this gene was found to be amplified in small-cell lung cancers. Alternate splicing of this gene results in multiple variants. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | Mycl |
| Official Name | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived [Source:MGI Symbol;Acc:MGI:96799] |
| Ensembl ID | ENSMUSG00000028654 |
| Bio databases IDs | |
| Aliases | v-myc avian myelocytomatosis viral oncogene lung carcinoma derived |
| Synonyms | bHLHe38, LMYC, LMYC1, MYCL1, MYCL proto-oncogene, bHLH transcription factor, v-myc avian myelocytomatosis viral oncogene lung carcinoma derived |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mycl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- Myc amino-terminal region
- protein binding
- Helix-loop-helix DNA-binding domain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- head and neck nonmelanoma skin cancer
- small cell lung cancer
- lower lip cancer
- diabetes mellitus
- carcinoma in situ
- epithelial cancer in situ
- lung squamous cell carcinoma
role in cell
- growth
- proliferation
- expression in
- differentiation
- cell cycle progression
- transformation
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mycl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of auditory receptor cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity