Pcbp2 Gene Summary [Mouse]
Enables C-rich single-stranded DNA binding activity. Acts upstream of or within peptidyl-lysine modification to peptidyl-hypusine and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human PCBP2 (poly(rC) binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pcbp2 |
| Official Name | poly(rC) binding protein 2 [Source:MGI Symbol;Acc:MGI:108202] |
| Ensembl ID | ENSMUSG00000056851 |
| Bio databases IDs | |
| Aliases | poly(rC) binding protein 2 |
| Synonyms | alphaCP-2, CP2, HNRNPE2, hnRNP X, HNRPE2, Hnrpx, poly(rC) binding protein 2, α cp2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- single-stranded DNA binding
- K homology (KH) RNA-binding domain, type I
- KH domain
- double-stranded DNA binding
- enzyme binding
- chromatin binding
- protein binding
- K homology RNA-binding domain
- metallochaperone
- DNA binding
- RNA binding
Pathways
Biological processes and signaling networks where the Pcbp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- pancreatic cancer
- gout
- bleeding
- infection by Newcastle disease virus
role in cell
- expression in
- activation in
- proliferation
- apoptosis
- ferroptosis
- peroxidation in
- molecular cleavage in
- growth
- cell death
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- Cytoplasm
- polysomes
- cytosol
- nucleoplasm
- interchromatin granule clusters
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcbp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- mRNA metabolic process
- innate immune response
- defense response to virus
- negative regulation of defense response to virus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin protein ligase binding
- RNA binding
- mRNA binding
- single-stranded DNA binding
- enzyme binding