BRF1 Gene Summary [Human]
This gene encodes one of the three subunits of the RNA polymerase III transcription factor complex. This complex plays a central role in transcription initiation by RNA polymerase III on genes encoding tRNA, 5S rRNA, and other small structural RNAs. The gene product belongs to the TF2B family. Several alternatively spliced variants encoding different isoforms, that function at different promoters transcribed by RNA polymerase III, have been identified. [provided by RefSeq, Jun 2011]
Details
| Type | Protein Coding |
| Official Symbol | BRF1 |
| Official Name | BRF1 RNA polymerase III transcription initiation factor subunit [Source:HGNC Symbol;Acc:HGNC:11551] |
| Ensembl ID | ENSG00000185024 |
| Bio databases IDs | |
| Aliases | BRF1 RNA polymerase III transcription initiation factor subunit |
| Synonyms | 2510002F24Rik, BRF, BRF1 general transcription factor IIIB subunit, BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit, CFDS, GTF3B, hBRF, HEL-S-76p, mTFIIIB90, TAF3B2, TAF3C, TAFIII90, TF3B90, TfIIIB, TFIIIB90 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transcription factor TFIIB repeat
- protein repeat
- Brf1-like TBP-binding domain
- transcription regulator
- TFIIB zinc-binding
- Cyclin box fold superfamily
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- zinc finger domain
- ERK phosphorylation site
- HMG2 like domain
- ERK2 binding domain
Pathways
Biological processes and signaling networks where the BRF1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cerebellofaciodental syndrome
- colorectal cancer
- ovarian neoplasia
- Huntington disease
- hereditary disorder
- lung neoplasm
- rectum neoplasm
- colorectal neoplasia
- global developmental delay with intellectual disability
role in cell
- expression in
- apoptosis
- proliferation
- transcription in
- growth
- cell viability
- senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromosome
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription initiation from RNA polymerase III promoter
- rRNA transcription
- DNA-dependent transcriptional preinitiation complex assembly
- transcription initiation, DNA-dependent
- positive regulation of transcription from RNA polymerase III promoter
- tRNA transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIIIB complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- TBP-class protein binding
- core RNA polymerase III binding transcription factor activity
- RNA polymerase III type 3 promoter sequence-specific DNA binding