Ap2a1 Gene Summary [Mouse]
Enables protein kinase binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in filopodium tip. Part of AP-2 adaptor complex. Is active in glutamatergic synapse and postsynaptic endocytic zone. Is expressed in liver and nervous system. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ap2a1 |
| Official Name | adaptor-related protein complex 2, alpha 1 subunit [Source:MGI Symbol;Acc:MGI:101921] |
| Ensembl ID | ENSMUSG00000060279 |
| Bio databases IDs | |
| Aliases | adaptor-related protein complex 2, alpha 1 subunit |
| Synonyms | Adaptin alpha a, Adaptin α a, adaptor-related protein complex 2, alpha 1 subunit, adaptor related protein complex 2 subunit alpha 1, adaptor related protein complex 2 subunit α 1, adaptor-related protein complex 2, α 1 subunit, ADTAA, Alpha a adaptin, Alpha-adaptin A, Ap-2, AP2-ALPHA, Ap2 alpha A, AP-2 alpha subunit, AP2-α, Ap2 α A, AP-2 α subunit, CLAPA1, LOC308578, α a adaptin, α-adaptin A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ap2a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- appendage domain
- binding protein
- protein kinase binding
- Adaptin C-terminal domain
- protein binding activity, bridging
- protein binding
- low-density lipoprotein receptor binding
- Adaptin N terminal region
- Alpha adaptin AP2, C-terminal domain
- transporter
Pathways
Biological processes and signaling networks where the Ap2a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by Human enterovirus 71
- infection by HBV genotype D
- infection by Dengue virus 2
role in cell
- degradation in
- endocytosis by
- development
- catabolism in
- endocytosis
- long term synaptic depression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- polyribosome fractions
- glutaminergic synapse
- endocytic vesicle membrane
- apical compartment
- basal compartment
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- apical membrane
- basolateral membrane
- lysosome membrane
- endosomal membrane
- synaptic vesicles
- secretory granules
- filopodia
- perikaryon
- ribbon synapse
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ap2a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- vesicle-mediated transport
- positive regulation of neuron projection development
- negative regulation of hyaluronan biosynthetic process
- endocytosis
- intracellular protein transport
- positive regulation of receptor-mediated endocytosis
- Golgi to endosome transport
Cellular Component
Where in the cell the gene product is active
- endolysosome membrane
- clathrin coat of trans-Golgi network vesicle
- clathrin-coated endocytic vesicle
- plasma membrane
- internal side of plasma membrane
- clathrin-coated endocytic vesicle membrane
- membrane
- filopodium tip
- cytosol
- AP-2 adaptor complex
- basolateral plasma membrane
- apical plasma membrane
- endocytic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- low-density lipoprotein particle receptor binding
- clathrin adaptor activity