Pabpc4 Gene Summary [Mouse]
Enables mRNA binding activity. Acts upstream of or within myeloid cell development and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in central nervous system; sensory organ; and tooth. Orthologous to human PABPC4 (poly(A) binding protein cytoplasmic 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Pabpc4 |
| Official Name | poly(A) binding protein, cytoplasmic 4 [Source:MGI Symbol;Acc:MGI:2385206] |
| Ensembl ID | ENSMUSG00000011257 |
| Bio databases IDs | |
| Aliases | poly(A) binding protein, cytoplasmic 4 |
| Synonyms | APP-1, iPABP, PABP4, poly(A) binding protein cytoplasmic 4, poly(A) binding protein, cytoplasmic 4, Poly(A)-binding protein, cytoplasmic 4 (inducible form), Polyadenylate-binding |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pabpc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- mRNA binding
- poly(A) binding protein
- protein binding
- heterogeneous nuclear ribonucleoprotein R, Q family
- Poly-adenylate binding protein, unique domain
- C-terminal domain of Poly(A)-binding protein
- translation regulator
- poly(U) binding protein
- polyadenylate binding protein, human types 1, 2, 3, 4 family
- RNA binding motif
- poly-U binding splicing factor, half-pint family
Pathways
Biological processes and signaling networks where the Pabpc4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- gastric adenocarcinoma
- chronic obstructive pulmonary disease
- gastric epithelial cancer
role in cell
- expression in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ribosome
- Nucleus
- cytosol
- stress granule
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pabpc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA processing
- regulation of mRNA stability
- blood coagulation
- translation
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- poly(A) RNA binding
- poly(C) RNA binding
- poly(U) RNA binding
- mRNA 3'-UTR binding