Elk4 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; and retina. Orthologous to human ELK4 (ETS transcription factor ELK4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elk4 |
| Official Name | ELK4, member of ETS oncogene family [Source:MGI Symbol;Acc:MGI:102853] |
| Ensembl ID | ENSMUSG00000026436 |
| Bio databases IDs | |
| Aliases | ELK4, member of ETS oncogene family |
| Synonyms | 2310011G17RIK, A130026I01RIK, BB162516, ELK4, member of ETS oncogene family, ETS transcription factor ELK4, LOC100502885, LOC100506969, SAP, SAP-1, sap1a, SRF accessory protein 1, TCF/SAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elk4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- net inhibitory domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- Ets-domain
- Box B domain
- CAD domain
Pathways
Biological processes and signaling networks where the Elk4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- metastatic prostate cancer
- prostate cancer
- colorectal neoplasia
- gastrointestinal neoplasia
role in cell
- binding in
- expression in
- number
- transcription in
- growth
- phosphorylation in
- activation in
- development
- positive selection
- selection
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elk4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity