Mogat1 Gene Summary [Mouse]
Enables 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. Acts upstream of or within diacylglycerol biosynthetic process. Located in endoplasmic reticulum and membrane. Orthologous to human MOGAT1 (monoacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mogat1 |
| Official Name | monoacylglycerol O-acyltransferase 1 [Source:MGI Symbol;Acc:MGI:1915643] |
| Ensembl ID | ENSMUSG00000012187 |
| Bio databases IDs | |
| Aliases | monoacylglycerol O-acyltransferase 1 |
| Synonyms | 0610030A14Rik, 1110064N14Rik, DGAT2L, DGAT2L1, mDC2, MGAT1, monoacylglycerol O-acyltransferase 1, WI1-2612I11.1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mogat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 2-acylglycerol O-acyltransferase
- diacylglycerol O-acyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- POTEE
- SERBP1
disease
- obesity
- androgenic alopecia
- insulin resistance
- weight gain
- uveal melanoma
- ocular melanoma
- senile lentigo
- polydipsia
role in cell
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mogat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- triglyceride biosynthetic process
- diacylglycerol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- 2-acylglycerol O-acyltransferase activity
- diacylglycerol O-acyltransferase activity