Mogat1 Gene Summary [Rat]
Predicted to enable 2-acylglycerol O-acyltransferase activity and diacylglycerol O-acyltransferase activity. Predicted to be involved in diacylglycerol biosynthetic process and triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human MOGAT1 (monoacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mogat1 |
| Official Name | monoacylglycerol O-acyltransferase 1 [Source:RGD Symbol;Acc:1311644] |
| Ensembl ID | ENSRNOG00000014692 |
| Bio databases IDs | |
| Aliases | monoacylglycerol O-acyltransferase 1 |
| Synonyms | 0610030A14Rik, 1110064N14Rik, DGAT2L, DGAT2L1, mDC2, MGAT1, monoacylglycerol O-acyltransferase 1, WI1-2612I11.1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mogat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 2-acylglycerol O-acyltransferase
- diacylglycerol O-acyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- POTEE
- SERBP1
disease
- obesity
- androgenic alopecia
- insulin resistance
- weight gain
- uveal melanoma
- ocular melanoma
- senile lentigo
- polydipsia
role in cell
- lipolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mogat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerol metabolic process
- triglyceride biosynthetic process
- diacylglycerol biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- 2-acylglycerol O-acyltransferase activity
- diacylglycerol O-acyltransferase activity