Helz2 Gene Summary [Mouse]
Predicted to enable RNA binding activity; RNA helicase activity; and exoribonuclease II activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in cytoplasm. Predicted to be active in P granule and cytosol. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and telencephalon. Orthologous to human HELZ2 (helicase with zinc finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Helz2 |
| Official Name | helicase with zinc finger 2, transcriptional coactivator [Source:MGI Symbol;Acc:MGI:2385169] |
| Ensembl ID | ENSMUSG00000027580 |
| Bio databases IDs | |
| Aliases | helicase with zinc finger 2, transcriptional coactivator |
| Synonyms | BC006779, helicase with zinc finger 2, helicase with zinc finger 2, transcriptional coactivator, LOC200213, mKIAA1769, mPDIP1, PDIP-1, PRIC285, RGD1306056 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Helz2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LXXLL motif
- transcription co-activator
- Zinc-finger double-stranded RNA-binding
- VacB and RNase II family 3'-5' exoribonucleases
- DNA helicase, putative
- U1 zinc finger
- protein binding
- RNA helicase
- AAA domain
- This domain is the catalytic domain of ribonuclease II
- exoribonuclease II
- RNB domain
- N-terminal helicase domain of the DEAD-box helicase superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Helz2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pneumonia
- hepatic steatosis
- rheumatoid arthritis
- weight gain
- diabetes mellitus
- hyperlipidemia
- polyglandular autoimmune syndrome type 1
role in cell
- transactivation in
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Helz2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- posttranscriptional gene silencing by RNA
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- P granule
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- exoribonuclease II activity
- DNA binding
- protein binding
- RNA binding
- RNA helicase activity
- metal ion binding
- ligand-dependent nuclear receptor transcription coactivator activity