Eif6 Gene Summary [Mouse]
The protein encoded by this gene is a eukaryotic translation initiation factor that regulates both ribosome biogenesis and translation, which are rate-limiting factors for cell growth. The encoded protein binds 60S ribosomes and prevents their association with 40S ribosomes. This gene may play a role in oncogenesis as well. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Eif6 |
| Official Name | eukaryotic translation initiation factor 6 [Source:MGI Symbol;Acc:MGI:1196288] |
| Ensembl ID | ENSMUSG00000027613 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 6 |
| Synonyms | 1110004P11, b(2)gcn, CAB, EIF3A, eukaryotic translation initiation factor 6, IF6, imc-415, ITGB4BP, p27BBP, p27(BBP) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IF6
- eIF-6 family
- ribosome binding
- protein binding
- translation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- major depression
- psoriasis
- hypoplasia
- luminal breast cancer
- hepatic fibrosis
- freckles
role in cell
- expression in
- binding in
- apoptosis
- growth
- function
- translation in
- colony formation
- maturation in
- synthesis in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosomal fraction
- nuclear fraction
- soluble fraction
- insoluble fractions
- Nucleus
- intermediate filaments
- nucleoplasm
- nucleoli
- nuclear lamina
- synapse
- cytoskeletal fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- negative regulation of translation involved in gene silencing by miRNA
- gene silencing by miRNA
- regulation of megakaryocyte differentiation
- regulation of glycolysis
- mature ribosome assembly
- translational initiation
- regulation of fatty acid biosynthetic process
- ribosomal subunit export from nucleus
- response to insulin stimulus
- maturation of 5.8S rRNA
- maturation of LSU-rRNA
- regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- lamin filament
- cytoplasm
- cytosol
- synapse
- nucleolus
- preribosome, large subunit precursor
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- ribosome binding
- ribosomal large subunit binding