Amotl1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Acts upstream of or within establishment of cell polarity involved in ameboidal cell migration and positive regulation of blood vessel endothelial cell migration. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Is expressed in brain and head. Orthologous to human AMOTL1 (angiomotin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Amotl1 |
| Official Name | angiomotin-like 1 [Source:MGI Symbol;Acc:MGI:1922973] |
| Ensembl ID | ENSMUSG00000013076 |
| Bio databases IDs | |
| Aliases | angiomotin-like 1 |
| Synonyms | 2310010G08Rik, 2310067L22Rik, 4932416D09Rik, angiomotin-like 1, JEAP, LOC108353604, mFLJ00155 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Amotl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- PPEY motif
- Angiomotin C terminal
- protein binding
- Bin/Amphiphysin/Rvs domain
- TATA element modulatory factor 1 TATA binding
- PDZ binding motif
- identical protein binding
- Valyl tRNA synthetase tRNA binding arm
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- non-melanoma skin cancer
- angioimmunoblastic T-cell lymphoma
role in cell
- apoptosis
- migration
- expression in
- activation in
- phosphorylation in
- growth
- signaling in
- cell proliferation
- migration by
- paracellular permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- intercellular junctions
- cytosol
- apical membrane
- lateral plasma membrane
- cytoplasmic vesicles
- tight junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Amotl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- Wnt receptor signaling pathway
- hippo signaling cascade
- regulation of cell migration
- actin cytoskeleton organization
- establishment of cell polarity involved in ameboidal cell migration
Cellular Component
Where in the cell the gene product is active
- tight junction
- cytoplasmic vesicle
- cytosol
- signalosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding