Cpsf6 Gene Summary [Mouse]
Predicted to enable exon-exon junction complex binding activity; mRNA binding activity; and ribosomal large subunit binding activity. Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA 3'-end processing; positive regulation of RNA export from nucleus; and protein heterotetramerization. Located in nucleus. Is expressed in several structures, including blastocyst; brain; early embryo; and retina nuclear layer. Orthologous to human CPSF6 (cleavage and polyadenylation specific factor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpsf6 |
| Official Name | cleavage and polyadenylation specific factor 6 [Source:MGI Symbol;Acc:MGI:1913948] |
| Ensembl ID | ENSMUSG00000055531 |
| Bio databases IDs | |
| Aliases | cleavage and polyadenylation specific factor 6 |
| Synonyms | 4733401N12RIK, CFIM, CFIM68, CFIM72, cleavage and polyadenylation specific factor 6, HPBRII-4, HPBRII-7, Pre-mRNA cleavage factor im, SPSF6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cpsf6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- binding protein
- RNA recognition motif
- mRNA binding
- protein binding
- ribosomal large subunit binding
- RNA binding
Pathways
Biological processes and signaling networks where the Cpsf6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- infection by HIV-1
- pain
- castration refractory prostate cancer
- metabolic syndrome X
- peripheral arterial disease
role in cell
- expression in
- phosphorylation in
- reactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perichromatin fibril
- interchromatin granule-associated zone
- perichromatin granule
- nuclear chromatin
- Cytoplasm
- spliceosomes
- nuclear foci
- interchromatin granules
- nucleoplasm
- nuclear bodies
- interchromatin granule clusters
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cpsf6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein tetramerization
- mRNA 3'-end processing
- mRNA processing
- protein heterotetramerization
- positive regulation of RNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- mRNA cleavage and polyadenylation specificity factor complex
- cytoplasm
- paraspeckles
- perichromatin fibrils
- nuclear speck
- membrane
- mRNA cleavage factor complex
- interchromatin granule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA binding
- ribosomal large subunit binding