Tmem175 Gene Summary [Mouse]
Enables potassium ion leak channel activity. Involved in lysosome organization; neuron cellular homeostasis; and potassium ion transmembrane transport. Predicted to be located in endosome membrane and lysosomal membrane. Predicted to be active in endosome and lysosome. Orthologous to human TMEM175 (transmembrane protein 175). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem175 |
| Official Name | transmembrane protein 175 [Source:MGI Symbol;Acc:MGI:1919642] |
| Ensembl ID | ENSMUSG00000013495 |
| Bio databases IDs | |
| Aliases | transmembrane protein 175 |
| Synonyms | 3010001K23Rik, hTMEM175, mTMEM175, RGD1309712, transmembrane protein 175 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem175 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- Endosomal/lysosomal potassium channel TMEM175
- channel/pore class transporter
- arachidonic acid binding
- protein binding
- ion channel
- hydrogen ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- non-insulin-dependent diabetes mellitus
- Parkinson disease
- metabolic syndrome X
- motor dysfunction
- REM sleep behavior disorder
- lewy body disease
role in cell
- apoptosis
- phosphorylation in
- loss
- production in
- mitophagy in
- mitochondrial respiration in
- pH
- depolarization in
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endosomes
- lysosome
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem175 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron homeostasis
- potassium ion transmembrane transport
- regulation of lysosomal lumen pH
- phagosome-lysosome fusion
- lysosomal lumen pH elevation
Cellular Component
Where in the cell the gene product is active
- endosome
- endosome membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- hydrogen ion channel activity
- potassium channel activity
- arachidonic acid binding
- potassium ion leak channel activity